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Dr. Lim contributed to a recent study published in Science. Significance: The synthesis and movement of mRNA play significant roles in various neural functions and altered dynamics may represent a backdrop of neurodegenerative conditions. However understanding the mechanistic roles of mRNA is currently hampered by the lack of techniques to observe the endogenous molecules in the native tissue environment. We report here the visualization of single molecules of mRNA for the first time in living tissue. This figure depicts imaging of the live neurons in the hippocampus of our transgenic mouse by two-photon microscopy where the transcription sites are switched on after pharmacological treatment. http://www.sciencemag.org/content/343/6169/422.full